Functional neuroanatomy of vocalization in patients with Parkinson's disease
Identifieur interne : 001522 ( Main/Exploration ); précédent : 001521; suivant : 001523Functional neuroanatomy of vocalization in patients with Parkinson's disease
Auteurs : I. Rektorova [République tchèque] ; M. Mikl [République tchèque] ; J. Barrett [Canada] ; R. Marecek [République tchèque] ; I. Rektor [République tchèque] ; T. Paus [Canada]Source :
- Journal of the neurological sciences [ 0022-510X ] ; 2012.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
In Parkinson's disease (PD) both speech production and self-monitoring of voiced speech are altered. Methods: In our previous study we used functional magnetic resonance imaging (fMRI) to examine which brain areas are involved in overt reading in nine female PD patients (mean age 66.0 ± 11.6 years) compared with eight age-matched healthy female controls (mean age 62.2 years ± 12.3). Here we performed the posthoc seed-based functional connectivity analysis of our data to assess the functional connectivity between the periaqueductal gray matter (PAG; i.e. the core subcortical structure involved in human vocalization) and other brain regions in the same groups of PD patients and controls. Results: In PD patients as compared with controls we observed increased connectivity between PAG and basal ganglia, posterior superior temporal gyrus, supramarginal and fusiform gyri and inferior parietal lobule on the right side. In the PD group, the connectivity strength in the right putamen and the right sypramarginal gyrus was correlated with variability of pitch while the connectivity strength in the right posterior superior temporal gyrus and in the right inferior parietal lobule was correlated with speech loudness. Conclusion: We observed functional reorganization in PD patients as compared with controls in both the motor basal ganglia-thalamo-cortical circuitry and cortical areas known to be engaged in-auditory and somatosensory feedback control of voiced speech. These changes were hemisphere-specific and might either reflect effects of dopaminergic treatment or at least partially successful compensatory mechanisms involved in early-stage PD.
Affiliations:
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Rektorova</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Applied Neurosciences Research Group, Central European Institute of Technology, CEITEC, Masaryk University</s1><s2>Brno</s2><s3>CZE</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>République tchèque</country><placeName><settlement type="city">Brno</settlement><region>Moravie</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>First Department of Neurology, Medical School of Masaryk University, St Anne's Hospital</s1><s2>Brno</s2><s3>CZE</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>République tchèque</country><placeName><settlement type="city">Brno</settlement><region>Moravie</region></placeName></affiliation></author><author><name sortKey="Mikl, M" sort="Mikl, M" uniqKey="Mikl M" first="M." last="Mikl">M. Mikl</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Applied Neurosciences Research Group, Central European Institute of Technology, CEITEC, Masaryk University</s1><s2>Brno</s2><s3>CZE</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>République tchèque</country><placeName><settlement type="city">Brno</settlement><region>Moravie</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>First Department of Neurology, Medical School of Masaryk University, St Anne's Hospital</s1><s2>Brno</s2><s3>CZE</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>République tchèque</country><placeName><settlement type="city">Brno</settlement><region>Moravie</region></placeName></affiliation></author><author><name sortKey="Barrett, J" sort="Barrett, J" uniqKey="Barrett J" first="J." last="Barrett">J. Barrett</name><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Psychology, University of Toronto</s1><s2>Mississauga, Ontario</s2><s3>CAN</s3><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Marecek, R" sort="Marecek, R" uniqKey="Marecek R" first="R." last="Marecek">R. Marecek</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Applied Neurosciences Research Group, Central European Institute of Technology, CEITEC, Masaryk University</s1><s2>Brno</s2><s3>CZE</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>République tchèque</country><placeName><settlement type="city">Brno</settlement><region>Moravie</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>First Department of Neurology, Medical School of Masaryk University, St Anne's Hospital</s1><s2>Brno</s2><s3>CZE</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>République tchèque</country><placeName><settlement type="city">Brno</settlement><region>Moravie</region></placeName></affiliation></author><author><name sortKey="Rektor, I" sort="Rektor, I" uniqKey="Rektor I" first="I." last="Rektor">I. Rektor</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Applied Neurosciences Research Group, Central European Institute of Technology, CEITEC, Masaryk University</s1><s2>Brno</s2><s3>CZE</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>République tchèque</country><placeName><settlement type="city">Brno</settlement><region>Moravie</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>First Department of Neurology, Medical School of Masaryk University, St Anne's Hospital</s1><s2>Brno</s2><s3>CZE</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>République tchèque</country><placeName><settlement type="city">Brno</settlement><region>Moravie</region></placeName></affiliation></author><author><name sortKey="Paus, T" sort="Paus, T" uniqKey="Paus T" first="T." last="Paus">T. Paus</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Rotman Research Institute, University of Toronto</s1><s2>Ontario</s2><s3>CAN</s3><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author></analytic><series><title level="j" type="main">Journal of the neurological sciences</title><title level="j" type="abbreviated">J. neurol. sci.</title><idno type="ISSN">0022-510X</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of the neurological sciences</title><title level="j" type="abbreviated">J. neurol. sci.</title><idno type="ISSN">0022-510X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Dysarthria</term><term>Feedback</term><term>Human</term><term>Nervous system diseases</term><term>Nuclear magnetic resonance imaging</term><term>Parkinson disease</term><term>Periaqueductal gray matter</term><term>Speech</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Dysarthrie</term><term>Pathologie du système nerveux</term><term>Homme</term><term>Parole</term><term>Imagerie RMN</term><term>Substance grise périaqueducale</term><term>Boucle réaction</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In Parkinson's disease (PD) both speech production and self-monitoring of voiced speech are altered. Methods: In our previous study we used functional magnetic resonance imaging (fMRI) to examine which brain areas are involved in overt reading in nine female PD patients (mean age 66.0 ± 11.6 years) compared with eight age-matched healthy female controls (mean age 62.2 years ± 12.3). Here we performed the posthoc seed-based functional connectivity analysis of our data to assess the functional connectivity between the periaqueductal gray matter (PAG; i.e. the core subcortical structure involved in human vocalization) and other brain regions in the same groups of PD patients and controls. Results: In PD patients as compared with controls we observed increased connectivity between PAG and basal ganglia, posterior superior temporal gyrus, supramarginal and fusiform gyri and inferior parietal lobule on the right side. In the PD group, the connectivity strength in the right putamen and the right sypramarginal gyrus was correlated with variability of pitch while the connectivity strength in the right posterior superior temporal gyrus and in the right inferior parietal lobule was correlated with speech loudness. Conclusion: We observed functional reorganization in PD patients as compared with controls in both the motor basal ganglia-thalamo-cortical circuitry and cortical areas known to be engaged in-auditory and somatosensory feedback control of voiced speech. These changes were hemisphere-specific and might either reflect effects of dopaminergic treatment or at least partially successful compensatory mechanisms involved in early-stage PD.</div></front></TEI><affiliations><list><country><li>Canada</li><li>République tchèque</li></country><region><li>Moravie</li><li>Ontario</li></region><settlement><li>Brno</li><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="République tchèque"><region name="Moravie"><name sortKey="Rektorova, I" sort="Rektorova, I" uniqKey="Rektorova I" first="I." last="Rektorova">I. Rektorova</name></region><name sortKey="Marecek, R" sort="Marecek, R" uniqKey="Marecek R" first="R." last="Marecek">R. Marecek</name><name sortKey="Marecek, R" sort="Marecek, R" uniqKey="Marecek R" first="R." last="Marecek">R. Marecek</name><name sortKey="Mikl, M" sort="Mikl, M" uniqKey="Mikl M" first="M." last="Mikl">M. Mikl</name><name sortKey="Mikl, M" sort="Mikl, M" uniqKey="Mikl M" first="M." last="Mikl">M. Mikl</name><name sortKey="Rektor, I" sort="Rektor, I" uniqKey="Rektor I" first="I." last="Rektor">I. Rektor</name><name sortKey="Rektor, I" sort="Rektor, I" uniqKey="Rektor I" first="I." last="Rektor">I. Rektor</name><name sortKey="Rektorova, I" sort="Rektorova, I" uniqKey="Rektorova I" first="I." last="Rektorova">I. Rektorova</name></country><country name="Canada"><region name="Ontario"><name sortKey="Barrett, J" sort="Barrett, J" uniqKey="Barrett J" first="J." last="Barrett">J. Barrett</name></region><name sortKey="Paus, T" sort="Paus, T" uniqKey="Paus T" first="T." last="Paus">T. Paus</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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